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An enema, also known as a clyster, is an injection of fluid into the lower bowel by way of the rectum. Also, the word enema can refer to the liquid so injected, as well as to a device for administering such an injection.. In standard medicine, the most frequent uses of enemas are to relieve constipation and for bowel cleansing before a medical examination or procedure; also, Pronunciation: /ˈɛnəmə/.